I was playing around with IE one day and I found out that you can override any homepage setting in Internet Options. If you have spyware, or come accross it frequently, then this is a very good tweak for you.
1. Right-click on the IE icon on your desktop.
2. Select Properties
3. Now in the "Target" box you will see "C:\Program Files\Internet Explorer\IEXPLORE.EXE" Now by adding the url of the site to the end of this it overrides any Homepage setting in internet options.
ex: "C:\Program Files\Internet Explorer\IEXPLORE.EXE" www.sdgamerz.tk
Editor's note: This works only with a custom shortcut to Internet Explorer not the default one that opens Internet Options when you choose "properties".