Forget the other tweaks that mask or disable the accessibility options only to allow it to run again once scandisk, windows update or another slip of the keyboard puts them into full swing and you are resting your finger on the shift key and ... never mind-
To remove the Accessibility options FOREVER-
1. Start button/ Run type in regedit
2. find HKEY_CURRENT_USER/Control Panel/Accessibility options
3. Delete the Accessibility Options folder.
NOTE- If you feel like there will EVER be a time you will need these features do NOT delete the folder-